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Inter try to get back on track against a Fiorentina side in crisis, as Lautaro Martinez and Francesco Pio Esposito take on Moise Kean and Albert Gudmundsson.
It kicks off at San Siro at 19.45 GMT.
You can follow all the build-up and action as it happens from today’s six Serie A games on the Liveblog.
The Nerazzurri had won seven competitive fixtures on the bounce until their ill-tempered 3-1 defeat to Napoli, with the reverberations still felt from a controversial penalty call.
Henrikh Mkhitaryan sustained an injury during that incident and will be out for a month, while Marcus Thuram and Matteo Darmian are also still sidelined.
That means Petar Sucic steps into the starting XI with Pio Esposito preferred to Ange-Yoan Bonny as partner for Lautaro Martinez.
Fiorentina are in crisis, as they are still without a single Serie A victory this season, scraping four draws and four defeats.
They did at least show a reaction at the weekend, fighting back from 2-0 down to snatch a point in stoppages with two penalties.
Kean and Gudmundsson again lead the attack, with ex-Inter winger Robin Gosens in support.
Tariq Lamptey and Christian Kouame are long-term absentees with knee ligament injuries.
Inter: Sommer; Akanji, Bisseck, Bastoni; Dumfries, Barella, Calhanoglu, Sucic, Dimarco; Lautaro Martinez, Pio Esposito
Fiorentina: De Gea; Comuzzo, Marì, Viti; Dodò, Sohm, Mandragora, Ndour, Gosens; Gudmundsson, Kean
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