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Juventus can catch Roma and Napoli in joint third place with a victory over Jamie Vardy’s Cremonese, so they look to Jonathan David and Kenan Yildiz.
It kicks off at the Allianz Juventus Stadium in Turin at 19.45 GMT (20.45 CET).
You can follow all the build-up and action as it happens on the Liveblog.
The Bianconeri have surged up the table under coach Luciano Spalletti, despite the hiccup when they were held 1-1 by Lecce.
They got right back on track crushing Sassuolo 3-0 and David was on target, putting the long drought and penalty miss behind him.
Francisco Conceicao, Dusan Vlahovic, Federico Gatti, Daniele Rugani and Arek Milik are still out of action.
The only real change to the starting XI from the midweek round is the return of Lloyd Kelly in defence, sending Teun Koopmeiners to the bench.
Weston McKennie and Fabio Miretti join Yildiz in supporting David upfront, as Lois Openda is ready to come on as a substitute.
Cremonese were promoted from Serie B last season via the play-offs, but have been a surprise, sitting fairly comfortably mid-table.
That is despite being without a win in five rounds, as last week they were leading 2-0 against Genoa only to be pegged back to a dramatic late 2-2 draw.
Martin Payero is out of action with flu symptoms, but Michele Collocolo returns to the squad after a long-term injury.
Vardy leads the attack just days after celebrating his 39th birthday, partnering Federico Bonazzoli in what looks like a 3-5-2 formation.
Juventus: Di Gregorio; Kalulu, Bremer, Kelly, Cambiaso; Locatelli, Thuram; McKennie, Miretti, Yildiz; David
Cremonese: Audero; Terracciano, Baschirotto, Bianchetti; Zerbin, Grassi, Johnsen, Bondo, Pezzella; Bonazzoli, Vardy
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