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Niklas Fullkrug makes his full Milan debut with Christian Pulisic and Ardon Jashari in the trip to Moise Kean’s struggling Fiorentina.
It kicks off at the Stadio Artemio Franchi at 14.00 GMT (15.00 CET).
You can follow all the build-up and action as it happens from today’s Serie A games on the Liveblog.
This is a big opportunity for the Rossoneri, as with Inter and Napoli facing each other this evening, they could leapfrog to top spot.
However, Max Allegri has to make changes, as Fikayo Tomori is suspended, with Santiago Gimenez a long-term absentee after ankle surgery.
Rafael Leao, Luka Modric, Adrien Rabiot and Christopher Nkunku are not at 100 per cent, so are on the bench.
It means January signing Fullkrug, who featured as a substitute in the 1-0 win away to Cagliari and 1-1 with Genoa, gets his first start for the club since the transfer from West Ham United.
His partner is Christian Pulisic rather than Leao, who is rested along with Modric ahead of Thursday’s rescheduled Week 16 clash with Como.
Jashari and Samuele Ricci therefore step into midfield, with Youssouf Fofana also benched after a midweek costly error.
Fiorentina are in penultimate place alongside Hellas Verona, but there have been signs of revitalisation in recent weeks.
They finally earned their first two wins of the season in Serie A, and are fresh off a dramatic midweek 2-2 draw at Lazio, decided by Pedro’s 95th-minute penalty.
Kean was benched for the last two matches, as he dealt with a personal matter that kept him away from training, but he returns to the starting XI with Albert Gudmundsson.
January signing Manor Solomon is on the bench again after his January move from Tottenham Hotspur, but Edin Dzeko and Tariq Lamptey are out of action.
Pablo Mari left the training camp last night to join Al-Hilal, but new arrival Marco Brescianini is on the bench for the first time after his transfer from Atalanta.
Fiorentina: De Gea; Dodo, Pongracic, Comuzzo, Gosens; Mandragora, Fagioli, Ndour; Parisi, Kean, Gudmundsson
Milan: Maignan; De Winter, Gabbia, Pavlovic; Saelemaekers, Loftus-Cheek, Jashari, Ricci, Estupinan; Pulisic, Fullkrug
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