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Napoli hope David Neres, Kevin De Bruyne and Scott McTominay can revitalise their fortunes in the Scudetto showdown with Lautaro Martinez and Ange-Yoan Bonny’s Inter.
It kicks off at the Stadio Diego Armando Maradona at 17.00 UK time (16.00 GMT).
You can follow all the build-up and action as it happens from today’s four Serie A games on the Liveblog.
These are the two sides who won the title most recently, and the battle to the last day for the trophy last term.
With Milan held to a 2-2 draw by Pisa last night, whoever wins this will go top of the table.
Napoli have struggled with balancing Champions League football and Serie A, losing four of their last seven competitive games.
Rasmus Hojlund, Stanislav Lobotka, Amir Rrahmani and Romelu Lukaku are still out injured, joined by Alex Meret after fracturing a finger in training.
David Neres is used as a False 9, as Antonio Conte drops Lorenzo Lucca after his red card for dissent in the 6-2 Champions League defeat to PSV Eindhoven.
Billy Gilmour again takes the midfield reins with De Bruyne and McTominay.
Inter started the season on the wrong foot with back-to-back losses against Udinese and Juventus, but have been on a roll ever since.
They’ve won their last seven official matches in a row, beating Roma in a head-to-head for top spot and then comfortably sweeping Union Saint-Gilloise aside 4-0 on Tuesday.
Marcus Thuram and Matteo Darmian are still on the treatment table, so Ange-Yoan Bonny gets the nod with Lautaro Martinez, sending Francesco Pio Esposito – who is from the Naples area – onto the bench.
There was some squad rotation midweek, so the likes of Manuel Akanji, Federico Dimarco, Nicolò Barella and Henrikh Mkhitaryan are well rested.
Napoli have not beaten Inter since a 3-1 result here in May 2023, followed by two losses including the Supercoppa Italiana Final and three consecutive 1-1 draws.
In fact, the Partenopei have won only one of their last 12 Serie A meetings with the Nerazzurri, home and away.
Napoli: Milinkovic-Savic; Di Lorenzo, Buongiorno, Juan Jesus, Spinazzola; Gilmour; Politano, Anguissa, De Bruyne, McTominay; Neres
Inter: Sommer; Akanji, Acerbi, Bastoni; Dumfries, Barella, Calhanoglu, Mkhitaryan, Dimarco; Lautaro Martinez, Bonny
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