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Juventus try to end their nine-match winless streak with Dusan Vlahovic and Jonathan David together, leaving Kenan Yildiz on the bench, as Lazio look to Mattia Zaccagni and Boulaye Dia.
It kicks off at the Stadio Olimpico at 19.45 GMT.
You can follow all the build-up and action as it happens from today’s Serie A games on the Liveblog.
It is a poor period of form for the Bianconeri, who are without a single victory in nine games between Serie A and the Champions League.
There were at least improvements in the performance when falling 1-0 to Real Madrid midweek, but Igor Tudor reshuffles the squad against his former club.
Some of those decisions are forced upon him, as Kenan Yildiz is struggling with a knee issue and finally gets some rest.
Gleison Bremer, Juan Cabal, Arek Milik and Carlo Pinsoglio are still out of action, but Manuel Locatelli and Francisco Conceicao return to the starting XI.
The biggest change is having two centre-forwards together, Vlahovic and David, while Mattia Perin makes his return in goal.
Lazio have their fair share of problems too, as although they are unbeaten in three, that included back-to-back stalemates against Torino and Atalanta.
Maurizio Sarri has a crowded treatment room, missing Nuno Tavares, Matteo Cancellieri, Taty Castellanos, Nicolò Rovella, Samuel Gigot and Fisayo Dele-Bashiru.
Having to make do, Adam Marusic and Manuel Lazzari are the full-backs, with Toma Basic going from unwanted player to permanent midfield presence.
Gustav Isaksen completes the attack with Dia and Zaccagni.
Lazio: Provedel; Lazzari, Gila, Romagnoli, Marusic; Guendouzi, Cataldi, Basic; Isaksen, Dia, Zaccagni
Juventus: Perin; Kalulu, Gatti, Kelly; Conceiçao, Koopmeiners, Locatelli, McKennie, Cambiaso; Vlahovic, David
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