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Vanja Milinkovic-Savic adds to the Napoli injury crisis, as Scott McTominay supports Rasmus Hojlund with Giovane on the bench, while Juventus start Francisco Conceicao with Kenan Yildiz and Jonathan David.
It kicks off at the Allianz Juventus Stadium in Turin at 17.00 GMT (18.00 CET).
You can follow all the build-up and action as it happens from today’s Serie A games on the Liveblog.
This has always been a bitter grudge match, but takes on a new level now Luciano Spalletti and Antonio Conte are also facing their former clubs.
Only four points separate them in the Serie A table, after Juve’s surprise 1-0 defeat at Cagliari, but their morale was boosted by a Champions League victory over Benfica.
Dusan Vlahovic, Daniele Rugani and Arek Milik are still out of action, but Conceicao breaks back into the starting XI in place of Fabio Miretti.
David is again chosen rather than Lois Openda upfront, with Weston McKennie in his more advanced role helping Kenan Yildiz.
Napoli’s injury crisis is taking its toll, as they have won just one of their last five competitive matches, including Tuesday’s 1-1 with 10-man Copenhagen in the Champions League.
It keeps getting worse, as goalkeeper Vanja Milinikovic-Savic picked up a muscular problem in training, so Alex Meret gets his first game since September 28, himself just recovering from a shoulder injury and before that a fractured metatarsal.
David Neres is having ankle surgery, so they signed Giovane from Verona for €20m and he is rushed straight onto the bench.
Matteo Politano, Amir Rrahmani, Pasquale Mazzocchi, Kevin De Bruyne, Andre Frank Zambo Anguissa and Billy Gilmour are also absent, while Noa Lang and Lorenzo Lucca left.
It means youth academy product Antonio Vergara starts his third game in a row with Eljif Elmas and Hojlund.
Juventus: Di Gregorio; Kalulu, Bremer, Kelly, Cambiaso; Locatelli, Thuram; Conceicao, McKennie, Yildiz; David
Napoli: Meret; Di Lorenzo, Buongiorno, Juan Jesus; Gutierrez, Lobotka, McTominay, Spinazzola; Vergara, Elmas; Hojlund
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