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Inter go head-to-head with Como and there are only three points separating them, as Lautaro Martinez and Marcus Thuram take on Alvaro Morata and Nico Paz.
It kicks off at San Siro at 17.00 GMT.
You can follow all the build-up and action as it happens from today’s three Serie A games on the Liveblog.
This is a surprising showdown for fourth place, because there are just three points between them in the table going into Week 14.
Cristian Chivu had to rotate the squad for the midweek 5-1 Coppa Italia win over Venezia.
Thuram scored a brace in that game and starts again with Lautaro Martinez, who had been rested.
Henrikh Mkhitaryan made his comeback there too, but is initially benched here for Piotr Zielinski, with Denzel Dumfries, Matteo Darmian and Raffaele Di Gennaro injured.
The big change is Luis Henrique gets his second consecutive Serie A start on the right wing.
Como have surged up the standings with a 5-1 victory away to Torino and 2-0 win against Sassuolo, taking their unbeaten run to 11 rounds.
Sergi Roberto and Edoardo Goldaniga are still out of action, but Ivan Smolcic returns from suspension.
Assane Diao is also back on the bench after his injury lay-off.
The big star is Nico Paz, who was heavily linked with moves to Inter and Tottenham Hotspur, but would seem to be heading back to Real Madrid in the summer.
The 21-year-old has a remarkable tally of five goals and five assists in 13 Serie A games this season, and is now a regular in the Argentina squad along with Lautaro Martinez.
Inter: Sommer; Akanji, Acerbi, Bastoni; Luis Henrique, Barella, Calhanoglu, Zielinski, Dimarco; Thuram, Lautaro Martinez
Como: Butez; Posch, Ramon, Diego Carlos, Valle; Perrone, Da Cunha; Addai, Paz, Rodriguez; Morata
FIFA World Cup
