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Juventus rely on Kenan Yildiz, Jonathan David and Francisco Conceicao in a change of tactics for the trip to Como where Nico Paz and Alvaro Morata lead the way.
It kicks off at the Stadio Sinigaglia at 11.30 UK time (10.30 GMT).
You can follow all the build-up and action as it happens from today’s five Serie A games on the Liveblog.
The Bianconeri have a huge opportunity to go joint top of the table with Inter, Napoli and Roma with a victory, but it is going to be tough against Cesc Fabregas’ team.
Gleison Bremer, Edon Zhegrova, Juan Cabal, Fabio Miretti, Arek Milik and Carlo Pinsoglio are out of action, leaving relatively few alternatives.
This prompts coach Igor Tudor to reshuffle his tactics, adopting a four-man defence.
Kenan Yildiz was in sparkling form for Turkey on international duty and leads the way with Jonathan David and Conceicao, while Teun Koopmeiners drops deeper to help the midfield.
Como stalled their progress recently with a pair of 1-1 draws against Cremonese and Atalanta.
They too have concerns, because Jesus Rodriguez is suspended along with coach Fabregas, who has to watch from the stands.
Jayden Addai, Sergi Roberto, Assane Diao and Alberto Dossena are all injured, meaning three of the four wide forwards are out of action.
They therefore improvise for what looks like a 3-5-2, pushing full-back Mergem Vojvoda into a more advanced role, with Nico Paz and former Juventus striker Morata upfront.
Como: Butez; Smolcic, Ramon, Kempf; Vojvoda, Da Cunha, Perrone, Caqueret, Alberto Moreno; Paz, Morata
Juventus: Di Gregorio; Kalulu, Rugani, Kelly, Cambiaso; Koopmeiners, Locatelli, K Thuram; Conceicao, David, Yildiz
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