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Roma are forced to make changes for the trip to Cagliari, as Tommaso Baldanzi and Kostas Tsimikas step in with Matias Soulé and Lorenzo Pellegrini.
It kicks off at the Unipol Domus Arena at 14.00 GMT.
You can follow all the build-up and action as it happens from today’s Serie A games on the Liveblog.
The Giallorossi had been top of the Serie A table until their 1-0 home defeat to Napoli last week, confirming their difficulties in the big games after losses to Inter and AC Milan too.
With a Europa League trip to Celtic coming up on Thursday, they are resting Paulo Dybala, with Wesley joining Artem Dovbyk and Angelino on the treatment table.
It means only ex-Liverpool man Kostas Tsimikas is available for the left flank, while Baldanzi is used as a False 9, supported by Soulé and Pellegrini.
Cagliari are without a win in nine rounds, managing just four draws in that period, and are fresh off a 2-1 defeat to Juventus.
They were in action midweek in the Coppa Italia, holding Napoli to a 1-1 draw and only going out after a sudden death penalty shoot-out.
The bad news for coach Fabio Pisacane is that Yerry Mina remains injured and Mattia Felici is out for six months with a torn anterior cruciate ligament.
They join Luca Mazzitelli, Ze Pedro and long-term absentee Andrea Belotti in the stands today.
Michael Folorunsho and Marco Palestra return after they were rested midweek, supporting Sebastiano Esposito and Gennaro Borrelli.
Cagliari: Caprile; Zappa, Rodriguez, Luperto; Palestra, Deiola, Adopo, Folorunsho, Obert; Borrelli, Esposito
Roma: Svilar; Mancini, Ndicka, Hermoso; Celik, Koné, Cristante, Tsimikas; Soulé, Pellegrini; Baldanzi
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