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Francisco Conceicao joins Kenan Yildiz and Jonathan David upfront for Juventus in a showdown for position with Riccardo Orsolini’s high-flying Bologna.
It kicks off at the Stadio Dall’Ara at 19.45 GMT.
You can follow all the build-up and action as it happens from today’s five Serie A games on the Liveblog.
Going into this weekend, Bologna are two points ahead of Juve in the table, so it is a big clash for Champions League places.
Both teams are also coming off midweek European victories that boosted their confidence.
Juve really needed it after their Serie A defeat to Napoli, which left them languishing in seventh.
Daniele Rugani and Gleison Bremer returned to the bench in their 2-0 win over Pafos, but Dusan Vlahovic, Federico Gatti, Arek Milik and Carlo Pinsoglio are still out.
David scored in Europe and is again chosen to lead the attack with support from Kenan Yildiz and Conceicao.
Bologna stalled their Serie A progress in recent weeks with defeat to Cremonese and a 1-1 draw against 10-man Lazio.
Nicolò Casale limped off with a thigh strain in that game, joining Martin Vitik, Lukasz Skorupski and Remo Freuler on the absentee list.
Thijs Dallinga gets the nod upfront rather than Santiago Castro after Thursday’s 2-1 comeback Europa League success away to Celta Vigo.
Orsolini, Lewis Ferguson in a more advanced role and Nicolò Cambiaghi are in support.
Bologna: Ravaglia; Zortea, Heggem, Lucumí, Miranda; Pobega, Moro; Orsolini, Ferguson, Cambiaghi; Dallinga
Juventus: Di Gregorio; Kalulu, Kelly, Koopmeiners; McKennie, Locatelli, Thuram, Cambiaso; Conceiçao, Yildiz; David
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