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Christian Pulisic and Christopher Nkunku lead the Milan attack against Sassuolo, who reply with Alieu Fadera and Andrea Pinamonti.
It kicks off at 12:30 CET (11:30 GMT) at the Stadio Meazza in San Siro, Milan.
You can follow all the build-up and action as it happens from today’s five Serie A games on the Liveblog.
Gimenez, Fofana, Leao are unavailable for the Rossoneri, but while the Mexican’s return date remains unclear, Leao and Fofana will be available for the Supercoppa Italiana Final Four next week.
Sassuolo have travelled to San Siro without the injured Romagna, Skjellerup, Pieragnolo, Turati, Berardi and Boloca and their coach Fabio Grosso, a 2006 Italy World Cup winner, is serving a one-game ban.
Pulisic and Nkunku will start up front for Milan. Ruben Loftus-Cheek gets the nod in the middle of the park, pushing Samuele Ricci to the bench.
Cristian Volpato replaces the injured Berardi for Sassuolo.
Milan (3-5-2) Maignan; Tomori, Gabbia, Pavlović; Saelemaekers, Loftus-Cheek, Modrić, Rabiot, Bartesaghi; Nkunku, Pulisic.
Milan bench: Pittarella, Terracciano; Athekame, De Winter, Estupiñan, Odogu; Jashari, Ricci.
Sassuolo (4-3-3): Murić; Walukiewicz, Idzes, Muhamerović, Candé; Thorstvedt, Matić, Koné; Volpato, Pinamonti, Fadera.
Sassuolo bench: Satalino, Zacchi; Coulibaly, Doig, Odenthal; Iannoni, Lipani, Vranckx; Cheddira, Laurientié, Moro, Pierini.
FIFA World Cup
