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There is good and bad news for Inter, because while Henrikh Mkhitaryan is back after injury, Ange-Yoan Bonny is not making the trip to Pisa.
It kicks off on Sunday at 14.00 GMT at the Cetilar Arena.
The Nerazzurri are badly in need of a result after back-to-back defeats to AC Milan and Atletico Madrid in Serie A and the Champions League.
Denzel Dumfries, Matteo Darmian, Tomas Palacio and goalkeeper Raffaele Di Gennaro are still out of action.
The good news for Cristian Chivu is that midfielder Mkhitaryan is back in the squad after several weeks out with a muscular issue.
However, Sky Sport Italia report that striker Bonny is not making the trip to Tuscany, as he is suffering from flu symptoms.
It leaves only Marcus Thuram, Lautaro Martinez and Francesco Pio Esposito for the forward roles.
Bonny was signed from Parma for €23m plus add-ons during the summer and he has contributed an impressive four goals and six assists in 17 appearances between Serie A and the Champions League.
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