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Marcus Thuram and Ange-Yoan Bonny start for Inter in the trip to Borussia Dortmund, facing Serhou Guirassy and Jobe Bellingham.
It kicks off at the Westfalenstadion at 20.00 GMT (21.00 CET).
You can follow all the build-up and action as it happens from this game, Napoli-Chelsea, Monaco-Juventus and Union Saint-Gilloise-Atalanta on the Liveblog.
All the matches are played simultaneously in the final round of the league phase, as Inter slipped out of the top eight and must win to have any chance of avoiding the play-offs.
Denzel Dumfries, Hakan Calhanoglu and Nicolò Barella are injured, with Lautaro Martinez initially rested, also as he is on a yellow card.
Instead, Bonny steps in to partner Thuram, with Francesco Pio Esposito also ready to come off the bench.
Luis Henrique is confirmed on the right wing, with Petar Sucic and Piotr Zielinski in midfield together.
Inter had started the Champions League so well winning the opening four matches, but have now lost three on the bounce.
Borussia Dortmund are in 16th place, one point behind Inter going into this final game.
They are forced into some changes, as Daniel Svensson is suspended, while Marcel Sabitzer and Niklas Sule are injured.
A late addition to the absentee list is defender Waldemar Anton, who is suffering from an illness, so Ramy Bensebaini drops into a deeper role.
Guirassy leads the attack, with support from Jobe Bellingham, but Karim Adeyemi is benched.
Borussia Dortmund: Kobel; Emre Can, Schlotterbeck, Mane; Ryerson, Bellingham, Nmecha, Bensebaini; Beier, Silva; Guirassy
Inter: Sommer; Bisseck, Acerbi, Akanji; Luis Henrique, Sucic, Zielinski, Mkhitaryan, Dimarco; Thuram, Bonny
FIFA World Cup
