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Roma know a victory away to Panathinaikos would secure direct access to the Europa League Round of 16, so Matias Soulé starts with Lorenzo Pellegrini and Bryan Cristante.
It kicks off at the Spyros Louis stadium in Athens at 20.00 GMT (21.00 CET).
You can follow all the build-up and action as it happens from this game and Maccabi Tel-Aviv vs. Bologna on the Liveblog.
The Giallorossi go into the final round of the league phase in sixth place, so a win here will guarantee a place in the top eight and therefore by-passing the play-offs.
January signings Donyell Malen and Robinio Vaz are cup-tied for now, with Paulo Dybala, Manu Kone, Evan Ferguson, Artem Dovbyk, Mario Hermoso and Angelino injured.
Gian Piero Gasperini therefore uses Soulé as a false 9, supported by Pellegrini and in a more advanced role than usual Cristante.
Devyne Rensch has shaken off a minor issue to start, with Neil El Aynaoui also returning after Africa Cup of Nations duty.
Panathinaikos have already guaranteed at least a play-off spot and sit in 19th place, four points behind Roma.
Coach Rafa Benitez has to do without suspended Karol Swiderski, while Pedro Chirivella, Facundo Pellistri and ex-Sassuolo player Filip Djuricic are injured.
Former Milan captain Davide Calabria did not train over the last few days due to a viral infection.
Panathinaikos: Lafont; Palmer-Brown, Ingason, Touba; Katris, Bakasetas, Siopis, Kiriakopoulos; Pantovic, Zaroury
Roma: Gollini; Mancini, Ziolkowski, Ghilardi; Celik, El Aynaoui, Pisilli, Tsimikas; Cristante, Pellegrini; Soulé
FIFA World Cup
