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Napoli try to ride the wave of enthusiasm from winning the Supercoppa Italiana with Rasmus Hojlund and Scott McTominay as they visit Jamie Vardy’s high-flying Cremonese.
It kicks off at the Stadio Zini at 14.00 GMT (15.00 CET).
You can follow all the build-up and action as it happens from today’s four Serie A games on the Liveblog.
The Partenopei lost top spot with a 1-0 defeat to Udinese, but felt revitalised in the Supercoppa Italiana victory in Riyadh before the Christmas break.
They beat both AC Milan and Bologna by 2-0 scorelines to lift the trophy.
Now Antonio Conte has to carry that momentum into Serie A, despite the on-going injury crisis ruling out Andre Frank Zambo Anguissa, Billy Gilmour, Kevin De Bruyne and Alex Meret.
Romelu Lukaku, Sam Beukema and Mathias Olivera have not made the trip after their Supercoppa strains.
David Neres has been on spectacular form lately, scoring six goals in his last nine competitive games.
He completes the trident with Hojlund and Eljif Elmas, the latter preferred to Noa Lang.
Cremonese are one of the biggest surprise outfits in Serie A this season, sitting comfortably mid-table following promotion via the Serie B play-offs.
They have beaten Milan, Sassuolo and Bologna already, while holding Como, Atalanta and Lazio to draws.
Martin Payero returns from suspension, with Matteo Bianchetti shaking off an injury, but Jari Vandeputte has been struggling with flu this week.
Michele Collocolo is the only remaining absentee for coach Davide Nicola, along with suspended Federico Ceccherini.
Vardy is the star man upfront with four goals in the last nine Serie A games, joined by Antonio Sanabria rather than Federico Bonazzoli, but Alessio Zerbin is eager to impress, as he is on loan from Napoli.
Cremonese: Audero; Terracciano, Baschirotto, Bianchetti; Barbieri, Zerbin, Grassi, Payero, Pezzella; Sanabria, Vardy
Napoli: Milinkovic-Savic; Di Lorenzo, Rrahmani, Juan Jesus; Politano, Lobotka, McTominay, Spinazzola; Neres, Elmas; Hojlund
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