
Inter give Luis Henrique a rare start with Lautaro Martinez and Marcus Thuram as they try to shake off back-to-back defeats with this trip to Pisa.
It kicks off at the Cetilar Arena at 14.00 GMT.
You can follow all the build-up and action as it happens from this game, Atalanta-Fiorentina and Roma-Napoli on the Liveblog.
This has been a rough week for Cristian Chivu, who suffered painful defeats to rivals AC Milan and then away to Atletico Madrid in the Champions League.
They risk falling further behind the leading pack in Serie A, so need to get back on track here.
Denzel Dumfries, Tomas Palacios and Raffaele Di Gennaro are still out of action, joined by Ange-Yoan Bonny, who is suffering from flu symptoms.
The good news is the return of Henrikh Mkhitaryan after a month out with muscular problems.
After having Carlos Augusto preferred to replace Dumfries, summer signing Luis Henrique is finally given an opportunity to play on the right wing.
Lautaro Martinez is partnered by Thuram, with Hakan Calhanoglu and Petar Sucic in midfield.
Pisa have made themselves very hard to beat under coach Alberto Gilardino following promotion from Serie B last season.
There was a difficult start, with just two points in the opening six rounds, and only one victory over Cremonese on November 7.
However, they are unbeaten in six, including a 2-2 thriller against Milan, draws with Lazio, Torino and Sassuolo.
Daniel Denoon, Isak Vural, Mateus Lusuardi, Tomas Esteves, Ebenezer Akinsanmiro and Calvin Stengs are all out of action, but Marius Marin returns to the squad.
Veteran defender Raul Albiol brings experience to the side, with M’Bala Nzola upfront.
Pisa: Scuffet; Caracciolo, Albiol, Canestrelli; Touré, Piccinini, Aebischer, Marin, Angori; Meister, Nzola
Inter: Sommer; Akanji, Acerbi, Bastoni; Luis Henrique, Barella, Calhanoglu, Sucic, Dimarco; Lautaro Martinez, Thuram
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