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Antonio Conte revamps his Napoli tactics with Scott McTominay, Noa Lang and Rasmus Hojlund, as new Atalanta coach Raffaele Palladino relies on Ademola Lookman and Charles De Ketelaere.
It kicks off at the Stadio Diego Armando Maradona at 19.45 GMT.
You can follow all the build-up and action as it happens from today’s four Serie A games on the Liveblog.
The injury crisis has been getting to Napoli, as Billy Gilmour, Andre Frank Zambo Anguissa, Kevin De Bruyne, Alex Meret and Romelu Lukaku are out of action.
They struggled badly in recent weeks, winning only two of the last seven competitive games, scraping two draws from the last three.
The 2-0 defeat at Bologna going into the break for international duty knocked them off top spot and prompted Conte into a tactical reshuffle.
He goes for a 3-4-3 formation here, as Hojlund is flanked by Lang and David Neres, with McTominay and Stanislav Lobotka pulling the midfield strings.
Atalanta sacked coach Ivan Juric after going seven Serie A rounds without a victory, including back-to-back defeats against Udinese and Sassuolo.
Palladino was drafted in and makes his debut in his hometown, as he is from Naples.
Lookman tries to put the disappointment of Nigeria’s World Cup qualifiers behind him, as he starts in the trident attack with De Ketelaere and Mario Pasalic.
Giorgio Scalvini must postpone his return to the field after yet another muscular injury in training.
La Dea have a very odd record this season, as in all competition they have lost only three games, but also won only four, drawing the other eight.
This has left them languishing in 13th place in Serie A.
Curiously, Atalanta have won their last two trips to the Stadio Maradona, both by 3-0 scorelines in March and November 2024.
Napoli: Milinkovic-Savic; Beukema, Rrahmani, Buongiorno; Di Lorenzo, Lobotka, McTominay, Gutierrez; Neres, Hojlund, Lang
Atalanta: Carnesecchi; Djimsiti, Hien, Ahanor; Bellanova, Ederson, De Roon, Zappacosta; Pasalic; Lookman, De Ketelaere
FIFA World Cup
