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Inter look to Lautaro Martinez, Francesco Pio Esposito and Davide Frattesi trying to keep a perfect Champions League record against Kairat Almaty.
It kicks off at San Siro at 20.00 GMT.
You can follow all the build-up and action as it happens from this game and Olympique Marseille vs. Atalanta on the Liveblog.
The Nerazzurri have won all three of their Champions League fixtures so far this season without conceding a single goal against Ajax, Slavia Prague and Union Saint-Gilloise.
Kazakhstani side Kairat Almaty are arguably the easiest game in their calendar, having lost 4-1 to Sporting CP and 5-0 to Real Madrid, but did get their first point in a 0-0 with Pafos, who were down to 10 men for 86 minutes.
There is some squad rotation, but Lautaro Martinez leads the attack with Pio Esposito rather than Ange-Yoan Bonny, as Marcus Thuram is back on the bench after more than a month out.
Henrikh Mkhitaryan and Matteo Darmian are still on the treatment table, so Frattesi steps into midfield with Piotr Zielinski fresh from a goal to beat Verona.
This is a special day at San Siro, because Inter and AC Milan signed the sale agreement to purchase the land around the stadium, where they can begin building their new arena.
Kairat are dealing with an injury issue for captain Aleksandr Martynovich.
Joao Paulo and Elder Santana are long-term absentees with knee ligament tears.
They qualified for the Champions League after eliminating Slovan Bratislava and Celtic in the preliminary rounds, both on penalty shoot-outs.
Inter: Sommer; Bisseck, De Vrij, Carlos Augusto; Dumfries, Frattesi, Barella, Zielinski, Dimarco; Esposito, Lautaro Martinez
Inter bench: J Martinez, Calligaris, P Sucic, M Thuram, Luis Henrique, Bonny, Acerbi, Diouf, Calhanoglu, Akanji, Alexiou, Bastoni
Kairat Almaty: Anarbekov; Mrynskiy, Shirobokov, Sorokin, Luis Mata; Kassabulat, Arad; Gromyko, Jorginho, Satpayev; Edmilson
Kairat bench: Zarutskiy, Kalmurza, Kurgin, Sadybekov, Zaria, Baibek, D Glazer, Tapalov, Stanojev, Ricardinho
FIFA World Cup
