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Luciano Spalletti makes his debut on the Juventus bench with Dusan Vlahovic, Loic Openda and Filip Kostic upfront in a 4-3-3 formation, visiting Jamie Vardy’s giant-killers Cremonese without Kenan Yildiz.
It kicks off at the Stadio Giovanni Zini at 19.45 GMT.
You can follow all the build-up and action as it happens from this game, Udinese-Atalanta and Napoli-Como on the Liveblog.
It has been a traumatic few days for Juve, who sacked Igor Tudor on Monday, then ended their eight competitive match winless streak by beating Udinese 3-1 on Wednesday with caretaker manager Massimo Brambilla.
Spalletti was formally appointed on Thursday and held his presentation press conference yesterday, but immediately had fresh problems to deal with.
Kenan Yildiz and Lloyd Kelly would’ve been certain to start, but pulled out with knee and back issues respectively.
They join Gleison Bremer, Juan Cabal, Arek Milik and Carlo Pinsoglio on the treatment table.
Filip Kostic was given his first start of the whole season by Brambilla, and is again used here, but as part of a trident attack in what seems to be a 4-3-3 formation.
Openda is once more preferred to Jonathan David as the partner for Vlahovic, with Teun Koopmeiners stepping back into the midfield.
Manuel Locatelli plays, despite his chequered history with former Italy coach Spalletti.
Cremonese are unbeaten in three after holding Udinese and Atalanta to 1-1 draws, then earned a huge 2-0 victory away to Genoa in the midweek round.
That sent them into eighth place, as their only defeat this season was 4-1 away to Inter on October 4.
Coach Davide Nicola also has injuries to deal with, as Antonio Sanabria, Giuseppe Pezzella, Alessio Zerbin, Alberto Grassi, Michele Collocolo and Faris Moumbagna out of action.
Former Premier League winner and Leicester City legend Jamie Vardy leads the attack with Federico Bonazzoli, who bagged a brace at Marassi midweek.
The impressive Romano Floriani Mussolini gets a rare start in midfield.
Cremonese: Audero; Terracciano, Baschirotto, Bianchetti; Barbieri, Payero, Bondo, Vandeputte, Floriani Mussolini; Bonazzoli, Vardy
Juventus: Di Gregorio; McKennie, Kalulu, Gatti, Cambiaso; Koopmeiners, Locatelli, K Thuram; Openda, Vlahovic, Kostic
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