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Napoli are still decimated by injuries, but Scott McTominay returns with Kevin De Bruyne, Lorenzo Lucca and Matteo Politano away to PSV Eindhoven in the Champions League.
It kicks off at the PSV Stadion at 20.00 UK time (19.00 GMT).
You can follow all the build-up and action as it happens from this game and Union Saint-Gilloise vs. Inter on the Liveblog.
The Partenopei have run into problems recently, losing two of their last three Serie A games to be knocked off top spot, while in Europe they beat Sporting 2-1 after a 2-0 defeat down to 10 men against Manchester City.
Injuries are piling up, missing Rasmus Hojlund, Stanislav Lobotka, Amir Rrahmani and Romelu Lukaku, but at least McTominay has passed a fitness test after getting six stitches on his ankle at the weekend.
Lucca therefore starts upfront, supported by De Bruyne and Matteo Politano, but former PSV Eindhoven man Noa Lang is on the bench.
PSV Eindhoven are second in the Eredivisie this season and have struggled in the Champions League, losing 3-1 at home to Union Saint-Gilloise and drawing 1-1 away to Bayer Leverkusen.
They are missing Ruben van Bommel and Kiliann Sidillia, while Alassane Plea is a long-term absentee.
There are a few familiar faces in the squad, above all former Inter winger Ivan Perisic who is still going strong at age 36, and ex-Parma striker Dennis Man.
Their captain is ex-Bologna midfielder Jerdy Schouten, who plays in a deeper role in Eindhoven, with Milan flop Sergino Dest and on loan Roma left-back Anass Salah-Eddine.
There has already been trouble in Eindhoven, as overnight and this morning the local police arrested and expelled 230 Napoli supporters.
PSV Eindhoven: Kovar; Flamingo, Schouten, Gasiorowski, Salah-Eddine; Mauro Junior, Veerman; Man, Saibari, Perisic; Til
PSV bench: Olij, Schiks, Obispo, Dest, Pepi, Wanner, Driouech, Bajraktarevic, Bouadu, Nagalo
Napoli: Milinkovic-Savic; Di Lorenzo, Beukema, Buongiorno, Spinazzola; Gilmour; Politano, Anguissa, De Bruyne, McTominay; Lucca
Napoli bench: Meret, Ferrante, Gutierrez, Juan Jesus, Neves, Olivera, Elmas, Vergara, Ambrosino, Lang
FIFA World Cup
