Brighton came unstuck last weekend against Bournemouth so will be happy to be back on home ground against in-form Tottenham.
The Seagulls have lost one of their last 10 home games in the Premier League and beat Spurs home and away last season.
Thomas Frank won on his Champions League debut in midweek and must master the art of rotating his talented squad now – starting with a trip to the south coast.
Brighton lost versatile defender/midfielder Jack Hinshelwood to an early injury last week and he is set for some time on the sidelines.
Adam Webster and Solly March remain out, but Diego Gomez and Mats Wieffer are now fit and available.
Dominic Solanke is still missing for Spurs, while Frank may decide to bring the likes od Destiny Udogie and Joao Palhinha back in after they were on the bench in midweek.
Brighton starting XI: Verbruggen; Veltman, Van Hecke, Dunk, Kadioglu; Baleba, Ayari; Minteh, Rutter, Mitoma; Welbeck